USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P09486 USC-OGP 2-DE database:  P09486 P09486 General information about the entry View entry in simple text format Entry name SPRC_HUMAN Primary accession number P09486 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=SPARC; AltName: Full=Basement-membrane protein 40; Short=BM-40; AltName: Full=Osteonectin; Short=ON; AltName: Full=Secreted protein acidic and rich in cysteine; Flags: Precursor;. Gene name Name=SPARC Synonyms=ON Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0116: pI=4.71; Mw=37074 SPOT OGP-0127: pI=4.78; Mw=35152 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1199: pI=4.68; Mw=39787 Cross-references UniProtKB/Swiss-Prot P09486; SPRC_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name SPRC_HUMAN Primary accession number P09486 Secondary accession number(s) D3DQH9 Q6IBK4 Sequence was last modified on  July 1, 1989 (version 1) Annotations were last modified on  March 15, 2017 (version 187) Name and origin of the protein Description RecName: Full=SPARC; AltName: Full=Basement-membrane protein 40; Short=BM-40; AltName: Full=Osteonectin; Short=ON; AltName: Full=Secreted protein acidic and rich in cysteine; Flags: Precursor; Gene name Name=SPARC Synonyms=ON Encoded on Name=SPARC; Synonyms=ON Keywords 3D-structure; Basement membrane; Calcium; Complete proteome; Copper; Direct protein sequencing; Disease mutation; Disulfide bond; Extracellular matrix; Glycoprotein; Metal-binding; Osteogenesis imperfecta; Polymorphism; Reference proteome; Secreted; Signal. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL Y00755; CAA68724.1; -; mRNA EMBL J03040; AAA60570.1; -; mRNA EMBL M25746; AAA60993.1; ALT_SEQ; Genomic_DNA EMBL M25738; AAA60993.1; JOINED; Genomic_DNA EMBL M25739; AAA60993.1; JOINED; Genomic_DNA EMBL M25740; AAA60993.1; JOINED; Genomic_DNA EMBL M25741; AAA60993.1; JOINED; Genomic_DNA EMBL M25742; AAA60993.1; JOINED; Genomic_DNA EMBL M25743; AAA60993.1; JOINED; Genomic_DNA EMBL M25744; AAA60993.1; JOINED; Genomic_DNA EMBL M25745; AAA60993.1; JOINED; Genomic_DNA EMBL CR456799; CAG33080.1; -; mRNA EMBL CH471062; EAW61668.1; -; Genomic_DNA EMBL CH471062; EAW61669.1; -; Genomic_DNA EMBL CH471062; EAW61670.1; -; Genomic_DNA EMBL CH471062; EAW61672.1; -; Genomic_DNA EMBL BC004974; AAH04974.1; -; mRNA EMBL BC008011; AAH08011.1; -; mRNA EMBL BC072457; AAH72457.1; -; mRNA EMBL AL709729; -; NOT_ANNOTATED_CDS; mRNA CCDS CCDS4318.1; -; . PIR A32821; GEHUN; . RefSeq NP_001296372.1; NM_001309443.1; . RefSeq NP_001296373.1; NM_001309444.1; . RefSeq NP_003109.1; NM_003118.3; . UniGene Hs.111779; -; . PDB 1BMO; X-ray; 3.10 A; A/B=71-303 PDB 1NUB; X-ray; 2.80 A; A/B=71-303 PDB 1SRA; X-ray; 2.00 A; A=153-303 PDB 2V53; X-ray; 3.20 A; A=70-303 PDBsum 1BMO; -; . PDBsum 1NUB; -; . PDBsum 1SRA; -; . PDBsum 2V53; -; . ProteinModelPortal P09486; -; . SMR P09486; -; . BioGrid 112560; 10; . DIP DIP-46426N; -; . IntAct P09486; 11; . MINT MINT-3006855; -; . STRING 9606.ENSP00000231061; -; . iPTMnet P09486; -; . PhosphoSitePlus P09486; -; . UniCarbKB P09486; -; . BioMuta SPARC; -; . DMDM 129283; -; . OGP P09486; -; . EPD P09486; -; . MaxQB P09486; -; . PaxDb P09486; -; . PeptideAtlas P09486; -; . PRIDE P09486; -; . DNASU 6678; -; . Ensembl ENST00000231061; ENSP00000231061; ENSG00000113140; . GeneID 6678; -; . KEGG hsa:6678; -; . UCSC uc003lui.5; human; . CTD 6678; -; . DisGeNET 6678; -; . GeneCards SPARC; -; . HGNC HGNC:11219; SPARC; . HPA CAB002306; -; . HPA HPA002989; -; . HPA HPA003020; -; . MalaCards SPARC; -; . MIM 182120; gene; . MIM 616507; phenotype; . neXtProt NX_P09486; -; . OpenTargets ENSG00000113140; -; . PharmGKB PA36055; -; . eggNOG KOG4004; Eukaryota; . eggNOG ENOG41101WW; LUCA; . GeneTree ENSGT00510000046787; -; . HOVERGEN HBG002746; -; . InParanoid P09486; -; . OMA KDFPRRM; -; . OrthoDB EOG091G0CPG; -; . PhylomeDB P09486; -; . TreeFam TF319356; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-3000178; ECM proteoglycans; . Reactome R-HSA-3000497; Scavenging by Class H Receptors; . ChiTaRS SPARC; human; . EvolutionaryTrace P09486; -; . GeneWiki Osteonectin; -; . GenomeRNAi 6678; -; . PMAP-CutDB P09486; -; . PRO PR:P09486; -; . Proteomes UP000005640; Chromosome 5; . Bgee ENSG00000113140; -; . CleanEx HS_SPARC; -; . ExpressionAtlas P09486; baseline and differential; . Genevisible P09486; HS; . GO GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell; . GO GO:0009986; C:cell surface; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0071682; C:endocytic vesicle lumen; TAS:Reactome; . GO GO:0005576; C:extracellular region; NAS:UniProtKB; . GO GO:0005615; C:extracellular space; IBA:GO_Central; . GO GO:0016363; C:nuclear matrix; IDA:UniProtKB; . GO GO:0031091; C:platelet alpha granule; IDA:UniProtKB; . GO GO:0031093; C:platelet alpha granule lumen; TAS:Reactome; . GO GO:0031092; C:platelet alpha granule membrane; IDA:UniProtKB; . GO GO:0005509; F:calcium ion binding; IDA:UniProtKB; . GO GO:0005518; F:collagen binding; IDA:UniProtKB; . GO GO:0050840; F:extracellular matrix binding; IBA:GO_Central; . GO GO:0060348; P:bone development; IEA:Ensembl; . GO GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl; . GO GO:0030198; P:extracellular matrix organization; TAS:Reactome; . GO GO:0007507; P:heart development; IEA:Ensembl; . GO GO:0048839; P:inner ear development; IEA:Ensembl; . GO GO:0030324; P:lung development; IEA:Ensembl; . GO GO:0016525; P:negative regulation of angiogenesis; IDA:UniProtKB; . GO GO:0001937; P:negative regulation of endothelial cell proliferation; IDA:UniProtKB; . GO GO:0001503; P:ossification; IEA:Ensembl; . GO GO:0043473; P:pigmentation; IEA:Ensembl; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0010595; P:positive regulation of endothelial cell migration; IDA:UniProtKB; . GO GO:0006898; P:receptor-mediated endocytosis; TAS:Reactome; . GO GO:0022604; P:regulation of cell morphogenesis; IDA:UniProtKB; . GO GO:0046686; P:response to cadmium ion; IEA:Ensembl; . GO GO:0051592; P:response to calcium ion; IEA:Ensembl; . GO GO:0051591; P:response to cAMP; IEA:Ensembl; . GO GO:0034097; P:response to cytokine; IEA:Ensembl; . GO GO:0045471; P:response to ethanol; IEA:Ensembl; . GO GO:0051384; P:response to glucocorticoid; IEA:Ensembl; . GO GO:0009629; P:response to gravity; IEA:Ensembl; . GO GO:0033591; P:response to L-ascorbic acid; IEA:Ensembl; . GO GO:0010288; P:response to lead ion; IEA:Ensembl; . GO GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl; . GO GO:0043434; P:response to peptide hormone; IEA:Ensembl; . GO GO:0007165; P:signal transduction; IEA:InterPro; . GO GO:0042060; P:wound healing; IEA:Ensembl; . CDD cd00252; SPARC_EC; 1; . Gene3D 1.10.238.10; -; 1; . InterPro IPR011992; EF-hand-dom_pair; . InterPro IPR018247; EF_Hand_1_Ca_BS; . InterPro IPR003645; Fol_N; . InterPro IPR015369; Follistatin/Osteonectin_EGF; . InterPro IPR002350; Kazal_dom; . InterPro IPR001999; Osteonectin_CS; . InterPro IPR019577; SPARC/Testican_Ca-bd-dom; . Pfam PF09289; FOLN; 1; . Pfam PF00050; Kazal_1; 1; . Pfam PF10591; SPARC_Ca_bdg; 1; . SMART SM00274; FOLN; 1; . SMART SM00280; KAZAL; 1; . SUPFAM SSF100895; SSF100895; 1; . SUPFAM SSF47473; SSF47473; 1; . PROSITE PS00018; EF_HAND_1; 1; . PROSITE PS51465; KAZAL_2; 1; . PROSITE PS00612; OSTEONECTIN_1; 1; . PROSITE PS00613; OSTEONECTIN_2; 1; .

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• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
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